Microwave-assisted reactions: Efficient and versatile one-step synthesis of 8-substituted xanthines and substituted pyrimidopteridine-2,4,6,8-tetraones under controlled microwave heating

Ramadan Ahmed Mekheimer; Alaa M. Hayallah; Moustafa Sherief Moustafa; Saleh Mohammed Al-Mousawi; Mohamed Abd-Elmonem; Sara M. Mostafa; Fatma A. Abo Elsoud; Kamal Usef Sadek

doi:10.1515/gps-2021-0014

Microwave-assisted reactions: Efficient and versatile one-step synthesis of 8-substituted xanthines and substituted pyrimidopteridine-2,4,6,8-tetraones under controlled microwave heating

Ramadan Ahmed Mekheimer
, Alaa M. Hayallah
, Moustafa Sherief Moustafa
, Saleh Mohammed Al-Mousawi
, Mohamed Abd-Elmonem
, Sara M. Mostafa
, Fatma A. Abo Elsoud
, Kamal Usef Sadek

Kuwait University

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

We report herein a simple and efficient one-step synthesis of 8-substituted xanthines and substituted pyrimidopteridine-2,4,6,8-tetraones via reaction of 1,3-dimethyl-5,6-diaminouracil 1 with activated double bond systems 2 assisted by controlled microwave irradiation. The obtained heterocycles are privileged biologically relevant scaffolds.

Original language	English
Pages (from-to)	201-207
Number of pages	7
Journal	Green Processing and Synthesis
Volume	10
Issue number	1
DOIs	https://doi.org/10.1515/gps-2021-0014
State	Published - 1 Jan 2021

Keywords

5,6-diaminouracil
8-substituted xanthines
green synthesis
pyrimidopetridines

Funding Agency

Kuwait Foundation for the Advancement of Sciences

Access to Document

10.1515/gps-2021-0014

Cite this

Mekheimer, R. A., Hayallah, A. M., Moustafa, M. S., Al-Mousawi, S. M., Abd-Elmonem, M., Mostafa, S. M., Abo Elsoud, F. A., & Sadek, K. U. (2021). Microwave-assisted reactions: Efficient and versatile one-step synthesis of 8-substituted xanthines and substituted pyrimidopteridine-2,4,6,8-tetraones under controlled microwave heating. Green Processing and Synthesis, 10(1), 201-207. https://doi.org/10.1515/gps-2021-0014

@article{ce6a346723a04575922e38ac5a4ed7ad,

title = "Microwave-assisted reactions: Efficient and versatile one-step synthesis of 8-substituted xanthines and substituted pyrimidopteridine-2,4,6,8-tetraones under controlled microwave heating",

abstract = "We report herein a simple and efficient one-step synthesis of 8-substituted xanthines and substituted pyrimidopteridine-2,4,6,8-tetraones via reaction of 1,3-dimethyl-5,6-diaminouracil 1 with activated double bond systems 2 assisted by controlled microwave irradiation. The obtained heterocycles are privileged biologically relevant scaffolds.",

keywords = "5,6-diaminouracil, 8-substituted xanthines, green synthesis, pyrimidopetridines",

author = "Mekheimer, \{Ramadan Ahmed\} and Hayallah, \{Alaa M.\} and Moustafa, \{Moustafa Sherief\} and Al-Mousawi, \{Saleh Mohammed\} and Mohamed Abd-Elmonem and Mostafa, \{Sara M.\} and \{Abo Elsoud\}, \{Fatma A.\} and Sadek, \{Kamal Usef\}",

note = "Publisher Copyright: {\textcopyright} 2021 Ramadan Ahmed Mekheimer et al., published by De Gruyter 2021.",

year = "2021",

month = jan,

day = "1",

doi = "10.1515/gps-2021-0014",

language = "English",

volume = "10",

pages = "201--207",

journal = "Green Processing and Synthesis",

issn = "2191-9542",

publisher = "Walter de Gruyter GmbH",

number = "1",

}

Mekheimer, RA, Hayallah, AM, Moustafa, MS, Al-Mousawi, SM, Abd-Elmonem, M, Mostafa, SM, Abo Elsoud, FA & Sadek, KU 2021, 'Microwave-assisted reactions: Efficient and versatile one-step synthesis of 8-substituted xanthines and substituted pyrimidopteridine-2,4,6,8-tetraones under controlled microwave heating', Green Processing and Synthesis, vol. 10, no. 1, pp. 201-207. https://doi.org/10.1515/gps-2021-0014

Microwave-assisted reactions: Efficient and versatile one-step synthesis of 8-substituted xanthines and substituted pyrimidopteridine-2,4,6,8-tetraones under controlled microwave heating. / Mekheimer, Ramadan Ahmed; Hayallah, Alaa M.; Moustafa, Moustafa Sherief et al.
In: Green Processing and Synthesis, Vol. 10, No. 1, 01.01.2021, p. 201-207.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Microwave-assisted reactions

T2 - Efficient and versatile one-step synthesis of 8-substituted xanthines and substituted pyrimidopteridine-2,4,6,8-tetraones under controlled microwave heating

AU - Mekheimer, Ramadan Ahmed

AU - Hayallah, Alaa M.

AU - Moustafa, Moustafa Sherief

AU - Al-Mousawi, Saleh Mohammed

AU - Abd-Elmonem, Mohamed

AU - Mostafa, Sara M.

AU - Abo Elsoud, Fatma A.

AU - Sadek, Kamal Usef

PY - 2021/1/1

Y1 - 2021/1/1

N2 - We report herein a simple and efficient one-step synthesis of 8-substituted xanthines and substituted pyrimidopteridine-2,4,6,8-tetraones via reaction of 1,3-dimethyl-5,6-diaminouracil 1 with activated double bond systems 2 assisted by controlled microwave irradiation. The obtained heterocycles are privileged biologically relevant scaffolds.

AB - We report herein a simple and efficient one-step synthesis of 8-substituted xanthines and substituted pyrimidopteridine-2,4,6,8-tetraones via reaction of 1,3-dimethyl-5,6-diaminouracil 1 with activated double bond systems 2 assisted by controlled microwave irradiation. The obtained heterocycles are privileged biologically relevant scaffolds.

KW - 5,6-diaminouracil

KW - 8-substituted xanthines

KW - green synthesis

KW - pyrimidopetridines

UR - https://www.scopus.com/pages/publications/85102838218

U2 - 10.1515/gps-2021-0014

DO - 10.1515/gps-2021-0014

M3 - Article

AN - SCOPUS:85102838218

SN - 2191-9542

VL - 10

SP - 201

EP - 207

JO - Green Processing and Synthesis

JF - Green Processing and Synthesis

IS - 1

ER -

Microwave-assisted reactions: Efficient and versatile one-step synthesis of 8-substituted xanthines and substituted pyrimidopteridine-2,4,6,8-tetraones under controlled microwave heating

Abstract

Keywords

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