Identification of Metabolites for Diagnosis and Treatment for Sleep Apnea

The present subject matter relates to a method of diagnosing and treating sleep apnea (SA) in a subject. The method may include determining whether the subject needs a Polysomnography by obtaining a biological sample from the subject to determine if the subject has a metabolite selected from the group consisting of PC-O (38:3), SM (43:1), LPC (24:1), PC (46:1), and TG (44:1). Expression of one of the metabolites may be associated with the presence of SA in a subject. If the subject has a metabolite associated with the presence of SA, then the method includes conducting a Polysomnography on the subject to further determine if the subject has SA. If the subject is further determined to have SA, the method may further include treating the subject with a treatment of SA selected from the group consisting of ENT surgery, continuous positive airway pressure therapy, and bariatric surgery.