TY - JOUR
T1 - Autoantibodies against type I IFNs in patients with life-threatening COVID-19
AU - Milieu Intérieur Consortium
AU - CoV-Contact Cohort
AU - Amsterdam UMC Covid-19 Biobank
AU - COVID Human Genetic Effort
AU - HGID Lab
AU - NIAID-USUHS Immune Response to COVID Group
AU - COVID Clinicians
AU - COVID-STORM Clinicians
AU - Imagine COVID-Group
AU - French COVID Cohort Study Group
AU - Bastard, Paul
AU - Rosen, Lindsey B.
AU - Zhang, Qian
AU - Michailidis, Eleftherios
AU - Hoffmann, Hans Heinrich
AU - Zhang, Yu
AU - Dorgham, Karim
AU - Philippot, Quentin
AU - Rosain, Jérémie
AU - Béziat, Vivien
AU - Manry, Jérémy
AU - Shaw, Elana
AU - Haljasmägi, Liis
AU - Peterson, Pärt
AU - Lorenzo, Lazaro
AU - Bizien, Lucy
AU - Trouillet-Assant, Sophie
AU - Dobbs, Kerry
AU - de Jesus, Adriana Almeida
AU - Belot, Alexandre
AU - Kallaste, Anne
AU - Catherinot, Emilie
AU - Tandjaoui-Lambiotte, Yacine
AU - Le Pen, Jeremie
AU - Kerner, Gaspard
AU - Bigio, Benedetta
AU - Seeleuthner, Yoann
AU - Yang, Rui
AU - Bolze, Alexandre
AU - Spaan, András N.
AU - Delmonte, Ottavia M.
AU - Abers, Michael S.
AU - Aiuti, Alessandro
AU - Casari, Giorgio
AU - Lampasona, Vito
AU - Piemonti, Lorenzo
AU - Ciceri, Fabio
AU - Bilguvar, Kaya
AU - Lifton, Richard P.
AU - Vasse, Marc
AU - Smadja, David M.
AU - Migaud, Mélanie
AU - Hadjadj, Jérome
AU - Terrier, Benjamin
AU - Duffy, Darragh
AU - Quintana-Murci, Lluis
AU - van de Beek, Diederik
AU - Roussel, Lucie
AU - Casanova, Jean Laurent
AU - Al-Mulla, Fahd
N1 - Publisher Copyright:
© 2020 American Association for the Advancement of Science. All rights reserved.
PY - 2020/10/23
Y1 - 2020/10/23
N2 - Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.
AB - Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.
UR - https://www.scopus.com/pages/publications/85094096675
U2 - 10.1126/science.abd4585
DO - 10.1126/science.abd4585
M3 - Article
C2 - 32972996
AN - SCOPUS:85094096675
SN - 0036-8075
VL - 370
JO - Science
JF - Science
IS - 6515
M1 - eabd4585
ER -
SDG 3 Good Health and Well-being