An evaluation of the acute in vivo toxicity of benzylidenechroman-4-ones, l-thiobenzylidenechroman-4-ones and benzylidenetetralones

A series of new compounds were evaluated for acute in vivo toxicity. Their synthesis ¹ and antifungal activity ² have previously been described by us. The naturally occurring class of compounds to which they belong-the benzylidenechroman-4-ones-have been identified as a potential source of new antifungal agents ³. These compounds were found to be less toxic, as judged by acute toxicity, than existing commercially available antifungals. A number of conclusions can be drawn about the relationship of structural changes in this series of compounds to increases or decreases in acute toxicity.